Genetic Rant & Roll – The Miniseries: Part 4

Back to the blind leading the blind (ha, ha) on this genetic business. Remember: I have no clue what I am talking about….but I talk a good game!😎

Not only do I not know, but the researchers don’t know much about the ARMS2 gene. What does it do? We don’t know. How does it affect AMD? We don’t know. What we know is, according to the Genetics Home Reference, mutations in and around the ARMS2 gene happen in accordance with the occurrence of AMD. That is the reason it is included in a genetic screening test for AMD. I have a moderately crappy copy of ARMS2 so whatever it does it only does it partially for me.

C2 and C3 are next.

C2 has me back to the complementary immune system. Oh, boy. The Genetic Home Reference, my current go to website, explains the complementary immune system is a group of proteins that destroy foreign objects (read germs), trigger inflammation and clean up after the battle. We are back to our macrophage ‘big eaters’ here. Errors in the gene can lead to clean-up problems. Sometimes good tissue is attacked in the clean-up (read autoimmune there). Sometimes the clean-up crew does a sloppy job. They are still working on the details.

Mine? I think they are the kind that do a sloppy job.

I would not be surprised if my propensity towards – shall we say lax? – housekeeping would extend to my eyes!😋 So far my entire genetic profile looks like it has a problem with bad housekeeping!

For those who are keeping score, I have moderately crappy results on C2.

C3 is another high risk gene for me. It is once again associated with the complementary immune system. This is the gene that can cause the immune system to be misguided. The explanation in the Genetic Home Reference suggested it is C2 that can cause good cells to be destroyed by ‘friendly fire’. In other words, not only does my complementary immune system clean things up poorly, but it can’t shoot straight! Sigh!

Let us do one more before I close: CETP. I admit I am flummoxed on this one. I went to Wikipedia to try to make sense of the stuff I read and they say it is also called plasma lipid transfer protein. Something to do with moving fat around. I would suppose a bad copy
has problems with dropping the stuff in inopportune places and not cleaning up after itself again.

You know what is weird, though? There are all sorts of websites listed that SELL the CETP gene. Weird. My CETP gene is actually GOOD, though, so I am not in the market.

Eight more to go (APOE is mentioned twice. Two variants). I will try to shed a little light on this stuff before the end of the day. I talk to the genetic testing people tomorrow and I need some sort of framework if I am going to make sense what they have to say. ( A la Vygotsky and his theories on zone of proximal development and scaffolding in learning if you psych nerds are interested! 😱 We try to support all kinds of learning! 😵)

More next time. Ready or not!

Next: Genetic Rant & Roll – The Miniseries: Part 5

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