by Joann Davis continued from Page 1
The final presentation by Dr. Mali was “New Treatments & Innovations for Macular Degeneration & Diabetic Eye Disease”.
- Iluvien – Steroid implant for DME. 0.19mg fluocinolone acetonide intravitreal implant lasts for 3 years, provides daily treatment, and provides 15 or more letter improvement at 24 months.
- Brolucizumab – Anti-VEGF that is more powerful than existing treatments in controlling bleeding. Studies show over 50% extend to 12 weeks. May get FDA approval this year.
- Abicipar Pegol has a new molecule – DARPin – and has allowed over 90% of patients to go to 12 weeks with stable vision. May get FDA approval next year.
- Faricmab – another new molecule – Anti-VEGF & ANG-2 combo injection. In trials has extended to 16 weeks.
- PDS – Port delivery with ranibizumab (Lucentis). This is exciting, as it uses a refillable implant that lasts for 6 months.
- Stem Cells – Early trials for Wet and Dry AMD have proven safety. Next trials will attempt to prove effectiveness in replacing damaged cells.
- Gene Therapy – This has been proven to work with other retinal conditions and is in early trials. A virus modifies cells to produce proteins lacking due to gene not working properly. Approved for retinitis pigmentosa. One goal is for your cells to make their own anti-VEGF protein.
- Future Home Monitoring – Home OCT for wet AMD to pinpoint need for next shot. Prototype has been built and FDA approval could be in next 2-3 years.
Dr. Mali ended with an Infomercial for the Mali Eyeglass Holder for Slit Lamp Microscope and Table. He invented this and you could use it at home to store your glasses anywhere you can use a clamp or Velcro to attach the eyeglass case. Prices start at $19.99.